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13th Congress of the Hungarian Neuroscience Society
20th - 22th Jan, 2011
Budapest, Hungary
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Physiological Days 9th - 11th Feb, 2011 Bratsilava, Slovak Republic Diabetes Meeting 14th - 16th Apr, 2011 Tihany, Hungary Romanian Physiological Congress 26th - 28th May, 2011 Targu Mures FAME 2011 8th - 11th Jun, 2011 Pécs, Hungary 8th IBRO World Congress of Neuroscience 14th - 18th Jul, 2011 Florence, Italy ESC Congress 2011 27th - 31th Aug, 2011 Paris, France 10th International Congress of the Polish Neuroscience Society 21th - 24th Sep, 2011 Lodz, Poland 13th Congress of the Hungarian Neuroscience Society 20th - 22th Jan, 2011 Budapest, Hungary Physiological Days 9th - 11th Feb, 2011 Bratsilava, Slovak Republic Diabetes Meeting 14th - 16th Apr, 2011 Tihany, Hungary Romanian Physiological Congress 26th - 28th May, 2011 Targu Mures FAME 2011 8th - 11th Jun, 2011 Pécs, Hungary 8th IBRO World Congress of Neuroscience 14th - 18th Jul, 2011 Florence, Italy ESC Congress 2011 27th - 31th Aug, 2011 Paris, France 10th International Congress of the Polish Neuroscience Society 21th - 24th Sep, 2011 Lodz, Poland |
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> Devices For Neural Research
NEU-02-CWS4 Cortical Wedge System for Grease Gap Method
- for studying of spontaneous electrical activity of the brain cortex
- cortex and axonal leads in two separate compartments
- D.C. potential difference is recorded
- ideal for pharmacological screening
- optional for field stimulation
- LOTUS EFFECT is used on slide-ways
- advanced pre-heater system
- ready for work set-up with specialized amplifier included in the system
This four-channel system is developed to study spontaneous electrical activity of cortex with axonal lead “in-vitro” conditions, using the grease-gap method.
The slice is placed into a two-compartment chamber so, that most of gray matter lies in one compartment and the white matter is in the other compartment. Generally, a wedge-shaped slice of cingulated cortex is used that also contains a piece of white matter (corpus callosum).
A Perspex barrier, well greased with silicon grease, provides a high resistance sealing between the two compartments. The two compartments are perfused independently with ACSF and bubbled with carbogen.
A non-polarizing Ag/ AgCI electrodes is placed into each compartment and the D.C. potential difference is recorded after amplification. Perfusion of the compartment containing gray matter with an excitatory compound for 1 to 2 minutes causes a potential change of 1 to 2mV. Responses to given agonist are highly reproducible after stabilization.
Dimensions
Width: 300 mm, length: 500 mm, height: 550 mm, weight: 5kg
Using magnesium-free medium, spontaneous depolarization appears (epileptiform activity). Substances, influencing epileptogenesis and those having neuroprotective effects may be studied under these circumstances. A four-channel extracellular amplifier enables to amplify the signals to be detected on oscilloscope or in computerized data acquisition system.
In case of request field stimulator electrodes can be built into the two compartment chambers.
